4 of the Best Cardiac Arrest RCTs of 2023

This papercut comes from an editorial in Resuscitation, where they chose four important multi centre RCTs with large sample sizes, published in 2023…. and not necessarily in their journal.

They were:

1. The INCEPTION Trial(1): Early initiation of Extracorporeal Life Support in refractory OHCA
2. The TAME Trial(2): Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest.
3. The ARREST Trial: A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation OHCA
4. The STEROHCA Trial: STEroid for Out-of-Hospital Cardiac Arrest.

Here is a summary of these four trials.

INCEPTION Trial

Extracorporeal cardiopulmonary resuscitation (ERCP), is sometimes considered to be the new paradigm, that we were looking for in resuscitation. Previous single centre RCT’s have found benefit of ECPR.