The HALT-IT Trial(1) is an important trial and one we should know well. It looks at the use of Tranexamic Acid (TXA) in gastrointestinal bleeding. Prior to this trial a Cochrane systematic review and meta analysis reported a significant reduction in mortality with TXA. This trial changed practice. (10 minute read)
What They Did
This was a randomised, double blind placebo-controlled trial in 154 hospitals and 15 countries.
N=12009
Patients received a loading dose of 1g of TXA or placebo (sodium chloride 0,9%) in 100mL of sodium chloride 0.9%, infused over 10 minutes. Then 125 mg/hr of TXA or placebo was transfused over 24 hours.
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