Post Intubation hypotension has been linked to induction agents, although the studies for this are few. It is moreso related to age and Shock Index. In a registry-based study there was no association between weight-based doses of etomidate and Ketamine and post intubation hypotension(1). In a recent retrospective study, there was no difference between Propofol and Ketamine(2).
“The objective of this study was to determine the hemodynamic associations of ketamine and etomidate after RSI when comparing full- vs reduced-dose induction agent.”
The Study
Mattson A E et al. Postintubation hypotension following rapid sequence intubation with full- vs reduced-dose induction agent. Am J health Syst Pharm. 2024 Jul 24:zxae217. doi: 10.1093/ajhp/zxae217. Online ahead of print
Bottom Line
There was no difference found in the rates of post intubation hypotension when using full or reduced doses of Ketamine and Etomidate.
