The Study: The CLOVERS Trial
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med 2023;388:499-510
Management of shock is changing and we are moving towards earlier use of vasopressors. The use of fluids and the volume of fluids that we should be using is uncertain. Liberal use of fluids has until now been the mainstay of treatment. New studies have challenged this approach, however the quality of studies has not been robust.
The Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) trial compared restrictive fluid therapy with early vasopressor use to liberal fluid therapy. The hypothesis in this paper is that a restrictive fluid strategy used in the first 24 hours, for sepsis-induced hypotension, would lead to lower mortality.
What They Did
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Watch the video by Dr Edwards on the CLOVER Trial
